PT  - JOURNAL ARTICLE
AU  - Joanne Schneider
AU  - Mary Patterson
AU  - Xavier F. Jimenez
TI  - Beyond depression: Other uses for tricyclic antidepressants
AID  - 10.3949/ccjm.86a.19005
DP  - 2019 Dec 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 807--814
VI  - 86
IP  - 12
4099  - http://www.ccjm.org/content/86/12/807.short
4100  - http://www.ccjm.org/content/86/12/807.full
SO  - Cleve Clin J Med2019 Dec 01; 86
AB  - Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.