RT Journal Article
SR Electronic
T1 Beyond depression: Other uses for tricyclic antidepressants
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 807
OP 814
DO 10.3949/ccjm.86a.19005
VO 86
IS 12
A1 Joanne Schneider
A1 Mary Patterson
A1 Xavier F. Jimenez
YR 2019
UL http://www.ccjm.org/content/86/12/807.abstract
AB Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.