TY - JOUR T1 - Beyond depression: Other uses for tricyclic antidepressants JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 807 LP - 814 DO - 10.3949/ccjm.86a.19005 VL - 86 IS - 12 AU - Joanne Schneider AU - Mary Patterson AU - Xavier F. Jimenez Y1 - 2019/12/01 UR - http://www.ccjm.org/content/86/12/807.abstract N2 - Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses. ER -