RT Journal Article SR Electronic T1 Urticaria and angioedema JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 529 OP 534 VO 59 IS 5 A1 Davidson, Andrew E. A1 Miller, S. David A1 Settipane, Guy A1 Klein, Donald YR 1992 UL http://www.ccjm.org/content/59/5/529.abstract AB Urticaria and angioedema are commonly seen in the outpatient setting. Their pathogenesis involves complex cellular and humoral factors. Diagnosis depends on historical information such as duration of symptoms, exacerbating factors, and atopy. While many etiologic factors have been implicated, in most chronic cases no specific etiology is found. This article reviews physical and hereditary syndromes and discusses therapeutic regimens based on the duration and severity of symptoms.