RT Journal Article
SR Electronic
T1 Syndrome of inappropriate secretion of antidiuretic hormone after infusional vincristine
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 643
OP 644
VO 59
IS 6
A1 Escuro, Ruben S.
A1 Adelstein, David J.
A1 Carter, Susan G.
YR 1992
UL http://www.ccjm.org/content/59/6/643.abstract
AB A 77-year-old woman with refractory multiple myeloma was treated with a 4-day continuous intravenous infusion of vincristine and doxorubicin and 4 days of oral dexamethasone. Nine days after her second cycle she presented with lethargy and weakness associated with hyponatremia. Evaluation revealed the syndrome of inappropriate secretion of antidiuretic hormone, which was attributed to the vincristine infusion. After normal serum sodium levels returned, further doxorubicin and dexamethasone chemotherapy without vincristine did not produce this complication.