PT  - JOURNAL ARTICLE
AU  - Cohn, Judith
AU  - Bone, Roger C.
TI  - New strategies in nonantibiotic treatment of gram-negative sepsis
DP  - 1992 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 608--615
VI  - 59
IP  - 6
4099  - http://www.ccjm.org/content/59/6/608.short
4100  - http://www.ccjm.org/content/59/6/608.full
SO  - Cleve Clin J Med1992 Nov 01; 59
AB  - Gram-negative bacterial infections are difficult to control and often lead to septic shock or septic syndrome. Many physiologic changes in sepsis are due to bacterial triggering of host responses. Improved understanding of these mechanisms has led to new treatment modalities that aim to block the runaway inflammatory process of sepsis. New therapeutic agents are currently being evaluated in animal and human studies. By combining these advances with adequate antibiotic therapy, it may be possible to improve overall survival in patients with gram-negative sepsis.