RT Journal Article
SR Electronic
T1 New strategies in nonantibiotic treatment of gram-negative sepsis
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 608
OP 615
VO 59
IS 6
A1 Cohn, Judith
A1 Bone, Roger C.
YR 1992
UL http://www.ccjm.org/content/59/6/608.abstract
AB Gram-negative bacterial infections are difficult to control and often lead to septic shock or septic syndrome. Many physiologic changes in sepsis are due to bacterial triggering of host responses. Improved understanding of these mechanisms has led to new treatment modalities that aim to block the runaway inflammatory process of sepsis. New therapeutic agents are currently being evaluated in animal and human studies. By combining these advances with adequate antibiotic therapy, it may be possible to improve overall survival in patients with gram-negative sepsis.