RT Journal Article SR Electronic T1 Functional heartburn: An underrecognized cause of PPI-refractory symptoms JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 799 OP 806 DO 10.3949/ccjm.86a.19006 VO 86 IS 12 A1 Gabbard, Scott A1 Vijayvargiya, Sonya YR 2019 UL http://www.ccjm.org/content/86/12/799.abstract AB Functional heartburn—persistent symptoms of esophageal reflux with no objective evidence of gastroesophageal reflux disease (GERD)—is the most common cause of failure of proton pump inhibitor (PPI) therapy, but it is often overlooked by internists and gastroenterologists.