RT Journal Article
SR Electronic
T1 A new intracellular flush solution improves renal transplant preservation
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 54
OP 58
VO 58
IS 1
A2 Ben H. Brouhard
A1 Peter N. Bretan
A1 Andrew C. Novick
YR 1991
UL http://www.ccjm.org/content/58/1/54.abstract
AB A new renal preservation flush solution (PB-2) has been developed to minimize the ischemic injury processes that occur during hypothermic storage and reperfusion and that can decrease renal viability and survival. Development of the new formulation took into account the intracellular and biological interactions that occur pre- and post-transplantation. PB-2 was compared with the conventional standardized Collins-2 flush solution in the preservation of autografts in dogs and was found to provide significantly improved renal recovery, viability, and survival. Studies to test the new solution in human renal allograft transplant preservation are planned.