RT Journal Article
SR Electronic
T1 Alpha- and beta-blocking agents: pharmacology and properties
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 337
OP 350
VO 58
IS 4
A2 Vidt, Donald G.
A2 Bakst, Alan
A1 Prichard, B.N.C.
YR 1991
UL http://www.ccjm.org/content/58/4/337.abstract
AB Adrenergic receptors have been separated into alpha and beta groups, which have then been further subdivided. Agents have been developed that block each type of receptor with varying degrees of specificity between the sub-types, leading to differences in pharmacodynamic profile. A more recent innovation has been the development of multiple action beta-blocking drugs, ie, those not only blocking the beta receptors but also posessing a peripheral vasodilator effect that may be due to alpha blockade, beta-2 stimulation, or a vasodilator action independent of either alpha or beta receptors.