RT Journal Article
SR Electronic
T1 Experimental limbic epilepsy: models, pathophysiologic concepts, and clinical relevance
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 521
OP 530
VO 58
IS 6
A1 Nayel, Mohamed
A1 Awad, Issam A.
A1 Larkins, Mark
A1 Lüders, Hans
YR 1991
UL http://www.ccjm.org/content/58/6/521.abstract
AB Complex partial seizures originating in the temporal lobe are one of the most common types of seizures in patients with epilepsy. They are frequently intractable to medical treatment and are increasingly considered for surgical therapy. These seizures are often associated with focal epileptogenicity in limbic structures (amydgala and hippocampus) or with rapid spread of seizure activity to these areas. Much research is being undertaken to better understand this disorder and to develop more effective approaches to diagnosis and treatment. Experimental work in animals has contributed to the understanding of epileptogenesis, the interictal state, and the homeostatic mechanisms that limit seizure activity.