PT - JOURNAL ARTICLE ED - Vidt, Donald G. AU - John A. Flynn AU - David B. Hellmann TI - Methotrexate in rheumatoid arthritis: when NSAIDs fail DP - 1995 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 351--359 VI - 62 IP - 6 4099 - http://www.ccjm.org/content/62/6/351.short 4100 - http://www.ccjm.org/content/62/6/351.full SO - Cleve Clin J Med1995 Nov 01; 62 AB - SUMMARY Methotrexate has become the agent of choice for rheumatoid arthritis that does not respond to nonsteroidal anti-inflammatory drugs. In appropriately selected patients and with diligent monitoring, methotrexate in low weekly doses is effective and has a much better safety profile than was originally perceived.