RT Journal Article SR Electronic T1 Methotrexate in rheumatoid arthritis: when NSAIDs fail JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 351 OP 359 VO 62 IS 6 A2 Vidt, Donald G. A1 Flynn, John A. A1 Hellmann, David B. YR 1995 UL http://www.ccjm.org/content/62/6/351.abstract AB SUMMARY Methotrexate has become the agent of choice for rheumatoid arthritis that does not respond to nonsteroidal anti-inflammatory drugs. In appropriately selected patients and with diligent monitoring, methotrexate in low weekly doses is effective and has a much better safety profile than was originally perceived.