TY - JOUR T1 - Methotrexate in rheumatoid arthritis: when NSAIDs fail JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 351 LP - 359 VL - 62 IS - 6 AU - John A. Flynn AU - David B. Hellmann A2 - Vidt, Donald G. Y1 - 1995/11/01 UR - http://www.ccjm.org/content/62/6/351.abstract N2 - SUMMARY Methotrexate has become the agent of choice for rheumatoid arthritis that does not respond to nonsteroidal anti-inflammatory drugs. In appropriately selected patients and with diligent monitoring, methotrexate in low weekly doses is effective and has a much better safety profile than was originally perceived. ER -