RT Journal Article SR Electronic T1 Thyroid dysfunction and lithium JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 32 OP 33 VO 50 IS 1 A1 Joseph R. Calabrese, Jr. A1 A. Dale Gulledge YR 1983 UL http://www.ccjm.org/content/50/1/32.abstract AB A patient with prelithium TSH and microsomal antibody abnormalities showed diminished thyroid function during lithium treatment but subsequently responded to thyroid supplements while still receiving lithium. This case demonstrates the necessity of routine screening for thyroid microsomal antibody titres before and during lithium treatment. In addition, it suggests that manic depressives with laboratory evidence of hypothyroidism prior to lithium treatment can be safely treated with lithium and thyroid supplements.