RT Journal Article SR Electronic T1 Necrobiotic granuloma formation at a collagen implant treatment site JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 163 OP 165 VO 50 IS 2 A1 Javier Ruiz-Esparza A1 Mary Bailin A1 Philip L. Bailin YR 1983 UL http://www.ccjm.org/content/50/2/163.abstract AB Collagen implantation in a patient for correction of facial wrinkles eventually resulted in necrobiotic granulomas at the treatment site which eventually resolved. Reaction at the test site had been negative.