RT Journal Article SR Electronic T1 Pretibial myxedema (elephantiasic form): treatment with cytotoxic therapy JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 183 OP 188 VO 50 IS 2 A1 Hanke, C. William A1 Bergfeld, Wilma F. A1 Guirguis, Marcelle N. A1 Lewis, L. James YR 1983 UL http://www.ccjm.org/content/50/2/183.abstract AB One of the four major components of Graves’ disease, prétibial myxedema (PTM), occurs in approximately 0.5% to 4.3% of patients with ophthalmic goiter and is often seen following treatment of the goiter. An advanced case of elephantiasic PTM is reported.