RT Journal Article SR Electronic T1 Macromolecular solute kinetics in on-line membrane plasma treatment systems JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 127 OP 133 VO 51 IS 1 A1 Paul S. Malchesky A1 Jeffery J. Starre A1 Jan Wojcicki A1 Andrzej Werynski A1 James W. Smith A1 Yasuhisa Abe A1 Yukihiko Nose YR 1984 UL http://www.ccjm.org/content/51/1/127.abstract AB Macromolecule removal by membrane plasma separation with on-line plasma filtration in rheumatoid arthritis patients undergoing cryofiltration treatments has been quantified. A single pool model provided good estimates of post-treatment concentrations of immunoglobulins, albumin, total globulin, and total cholesterol. Net generation of these solutes as well as rheumatoid factor and circulating immune complexes has been shown to be highly individual and related to intertreatment durations and concomitant drug therapy.