PT  - JOURNAL ARTICLE
AU  - Bhagwat, Arvind G.
AU  - Walia, Brij Nandia Singh
AU  - Koshy, Abraham
AU  - Banerji, Chandra Kanta
TI  - Will the real Indian childhood cirrhosis please stand up?
DP  - 1983 Sep 21
TA  - Cleveland Clinic Journal of Medicine
PG  - 323--337
VI  - 50
IP  - 3
4099  - http://www.ccjm.org/content/50/3/323.short
4100  - http://www.ccjm.org/content/50/3/323.full
SO  - Cleve Clin J Med1983 Sep 21; 50
AB  - Indian childhood cirrhosis (ICC), so named to reflect its ethnic origins, was found in 4 Caucasian siblings in the United States who died during the period 1958-1962. Since these children had not been exposed to copper (either endogenous or exogenous) and had no Indian ancestry, the disease at that time was classified as “cryptogenic cirrhosis.” Many years later, pathologic review suggested that the true diagnosis should have been ICC. Hence, Indian childhood cirrhosis is probably a misnomer. Because of the large influx of immigrants from the Indian subcontinent, Western pathologists should become more familiar with the true histologic and gross picture of ICC. The authors differentiate cryptogenic cirrhosis and cirrhosis of Indian childhood from ICC (which is not a true cirrhosis) with illustrative gross specimens and photomicrographs. Historical background and a comprehensive review of the literature are offered.