RT Journal Article
SR Electronic
T1 Gynecomastia and Leydig cell tumors in the adult
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 395
OP 399
VO 51
IS 2
A1 Steven W. Siegel
A1 Anthony J. Thomas, Jr.
YR 1984
UL http://www.ccjm.org/content/51/2/395.abstract
AB Two men with gynecomastia were evaluated at The Cleveland Clinic Foundation. Both were subsequently found to have a Leydig cell tumor of the left testis. One patient had previously undergone a testicular biopsy examination because of presumed infertility; the other had undergone the same type of examination due to a suspicious enlargement of the testicle. The results of these examinations had failed to reveal any evidence of a tumor. Endocrinologic manifestations of Leydig cell tumors are common and frequently present prior to the discovery of a testicular mass. These tumors are rare and usually benign. An orchiectomy is then curative and results in resolution of hormonal abnormalities in most cases. When malignant, Leydig cell tumors usually become evident by the presence of metastasis.