RT Journal Article SR Electronic T1 Endogenous Pseudoallescheria boydii endophthalmitis JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 197 OP 203 VO 53 IS 2 A1 Stern, Robert M. A1 Zakov, Z. Nicholas A1 Meisler, David M. A1 Hall, Geraldine S. A1 Martin, Amy YR 1986 UL http://www.ccjm.org/content/53/2/197.abstract AB The authors describe the clinicopathologic findings in a case of endogenous Pseudoallescheria boydii endophthalmitis that developed in a 31-year-old man following aortic valve replacement and aortic prosthetic graft insertion. The patient died from disseminated P boydii infection. The fungus was resistant to amphotericin B in vitro. Postmortem histologic and microbiologic studies suggested that the combination of pars plana vitrectomy and intravitreal instillation of miconazole (40 ng) had eradicated the organism from the vitreous cavity. In other instances of fungal endophthalmitis where isolates are resistant to amphotericin B, intravitreal miconazole and vitrectomy may be useful.