PT  - JOURNAL ARTICLE
AU  - Linden, Michael D.
AU  - Tubbs, Raymond R.
AU  - Weick, James K.
TI  - Large-Cell Lymphoma with Diffuse Sclerosis
DP  - 1986 Sep 21
TA  - Cleveland Clinic Journal of Medicine
PG  - 319--322
VI  - 53
IP  - 3
4099  - http://www.ccjm.org/content/53/3/319.short
4100  - http://www.ccjm.org/content/53/3/319.full
SO  - Cleve Clin J Med1986 Sep 21; 53
AB  - Malignant lymphoma with diffuse sclerosis and bulky disease is a relatively rare tumor characterized by an aggressive mediastinal mass with superior vena cava obstruction. The tumor is resistant to radiation or chemotherapy, and the prognosis is poor. To better understand the nature of the proliferating cell in aggressive large-cell lymphoma with diffuse sclerosis, we used frozen-section immunohistologic techniques to study tissue from a 24-year-old man who died of the disease. Immunotyping demonstrated a B-cell neoplasm (Til−, Leu5−, B1+, Leul4+). B-cell-subset immunotyping disclosed an absence of markers expressed earlier in B-cell maturation (B2-, LN2-, J 5− , I2−), but uniform expression of later, preplasma-cell, secretory blast-stage antigens (IgG+, kappa+, LN1+, PCA+). These immunohistologic observations may be helpful in interpreting biopsies of sclerosing lymphomas with mediastinal presentations.