RT Journal Article SR Electronic T1 Neutrophil Dysfunction JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 299 OP 306 VO 53 IS 3 A1 Katzin, William E. A1 Barna, Barbara P. A1 Clough, John D. A1 Clements, Mary A. YR 1986 UL http://www.ccjm.org/content/53/3/299.abstract AB The polymorphonuclear leukocyte (PMN), or neutrophil, plays a central role in the defense of the body against acute bacterial infection. PMNsalso migrate to sites of tissue necrosis and actively participate in the early stages of repair. They may have tumoricidal activity and thereby play a role in the immune surveillance which is thought to be important in controlling neoplastic disease. Two cases which illustrate defects in neutrophil motility and oxidative metabolism are described. A number of intrinsic neutrophil defects are reviewed.