PT  - JOURNAL ARTICLE
AU  - Clough, John D.
AU  - Couri, Joseph
AU  - Youssoufian, Hagop
AU  - Gephardt, Gordon N.
AU  - Tubbs, Raymond
TI  - Antibodies Against Nuclear Antigens: Association with Lupus Nephritis
DP  - 1986 Sep 21
TA  - Cleveland Clinic Journal of Medicine
PG  - 259--265
VI  - 53
IP  - 3
4099  - http://www.ccjm.org/content/53/3/259.short
4100  - http://www.ccjm.org/content/53/3/259.full
SO  - Cleve Clin J Med1986 Sep 21; 53
AB  - The predictive value of serological markers for the presence of Class IV (diffuse proliferative) glomerulonephritis in systemic lupus erythematosus (SLE) was investigated in a group of 96 patients with SLE. All patients with proteinuria greater than 1 g/24 hr, and/or urine sediment containing cellular casts or more than 6 erythrocytes/high-power field, and/or serum creatinine greater than 1.5 mg/dL (51 patients) underwent renal biopsy. Sixteen patients had Class IV glomerulonephritis. The combined presence of anti-native DNA, anti-Sm, and anti-RNP had a positive predictive value of 50.0% for Class IV nephritis (p = .0031), while the predictive value of negative anti-native DNA for absence of Class IV nephritis was 97.4% (p = .0019). We conclude that serological markers can be helpful in determining the need for renal biopsy in SLE.