RT Journal Article
SR Electronic
T1 Antibodies Against Nuclear Antigens: Association with Lupus Nephritis
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 259
OP 265
VO 53
IS 3
A1 Clough, John D.
A1 Couri, Joseph
A1 Youssoufian, Hagop
A1 Gephardt, Gordon N.
A1 Tubbs, Raymond
YR 1986
UL http://www.ccjm.org/content/53/3/259.abstract
AB The predictive value of serological markers for the presence of Class IV (diffuse proliferative) glomerulonephritis in systemic lupus erythematosus (SLE) was investigated in a group of 96 patients with SLE. All patients with proteinuria greater than 1 g/24 hr, and/or urine sediment containing cellular casts or more than 6 erythrocytes/high-power field, and/or serum creatinine greater than 1.5 mg/dL (51 patients) underwent renal biopsy. Sixteen patients had Class IV glomerulonephritis. The combined presence of anti-native DNA, anti-Sm, and anti-RNP had a positive predictive value of 50.0% for Class IV nephritis (p = .0031), while the predictive value of negative anti-native DNA for absence of Class IV nephritis was 97.4% (p = .0019). We conclude that serological markers can be helpful in determining the need for renal biopsy in SLE.