RT Journal Article SR Electronic T1 Anorectic drugs and valvular heart disease: A biological and clinical perspective JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 35 OP 41 VO 65 IS 1 A1 Wong, James A1 Reddy, S. Sethu K. A1 Klein, Allan L. YR 1998 UL http://www.ccjm.org/content/65/1/35.abstract AB The epidemiologic and pathologic evidence that fenfluramine and related drugs cause valvular heart disease is still speculative. However, at present, there is no alternative explanation for the cases of valvular disease found in patients taking these drugs, and there is evidence that similar substances can cause similar lesions. The manufacturer of fenfluramine and dexfenfluramine has prudently removed them from sale pending further studies.