PT - JOURNAL ARTICLE ED - Vidt, Donald G. AU - Franko, Thomas G. AU - Richter, Joel E. TI - Protoivpump inhibitors for gastric acid-related disease DP - 1998 Jan 01 TA - Cleveland Clinic Journal of Medicine PG - 27--34 VI - 65 IP - 1 4099 - http://www.ccjm.org/content/65/1/27.short 4100 - http://www.ccjm.org/content/65/1/27.full SO - Cleve Clin J Med1998 Jan 01; 65 AB - Proton-pump inhibitors are the most effective drugs introduced to date for suppressing gastric acid production. Although they are used to treat the same conditions as histamine type-2 receptor antagonists, they differ from the latter drugs in how they inhibit acid production, and in how they should be given. Initial concerns over potential ill effects of hypergastrinemia due to long-term acid suppression with proton-pump inhibitors have been unfounded.