PT  - JOURNAL ARTICLE
AU  - Wood, David P.
AU  - Novick, Andrew C.
AU  - Johnson, Douglas E.
AU  - Streem, Stevan B.
AU  - Steinmuller, Donald
TI  - Treatment of metastatic transitional cell carcinoma following renal transplantation
DP  - 1989 Jan 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 61--63
VI  - 56
IP  - 1
4099  - http://www.ccjm.org/content/56/1/61.short
4100  - http://www.ccjm.org/content/56/1/61.full
SO  - Cleve Clin J Med1989 Jan 01; 56
AB  - Renal transplantation was performed in a patient with a history of surgical excision for localized transitional cell carcinoma. The graft functioned well; however, metastatic transitional cell carcinoma developed following transplantation. The patient was treated sequentially with CISCA (cisplatin, Cy-toxan [cyclophosphamide], and Adriamycin [doxorubicin hydrochloride]) and M-VAC (methotrexate, vinblastine, Adriamycin, and cisplatin) with no alteration in maintenance immunosuppression. Full-dose chemotherapy was well tolerated, with no impairment of renal function, and a demonstrable reduction in tumor burden was achieved. The patient ultimately died of metastatic disease but enjoyed an excellent quality of life throughout the post-transplant period.