RT Journal Article SR Electronic T1 The diagnostic utility of c-ANCA in Wegener’s granulomatosis JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 135 OP 140 VO 65 IS 3 A2 Hoffman, Gary S. A1 Langford, Carol A. YR 1998 UL http://www.ccjm.org/content/65/3/135.abstract AB Anti-neutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) have been found to have a high degree of sensitivity and specificity for Wegener’s granulomatosis. Nevertheless, despite the attraction of using this autoantibody as a diagnostic test, in almost all instances it should not be used in place of a biopsy to diagnose Wegener’s granulomatosis.