RT Journal Article
SR Electronic
T1 Cyclosporine nephrotoxicity
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 89
OP 95
VO 56
IS 1
A1 Steinmuller, Donald R.
YR 1989
UL http://www.ccjm.org/content/56/1/89.abstract
AB Cyclosporine is a potent and useful immunosuppressive agent used primarily in Conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes. This review outlines the clinical syndromes and discusses ways to minimize nephrotoxicity in patients receiving cyclosporine.