PT  - JOURNAL ARTICLE
ED  - Markman, Maurie
AU  - David M. Peereboom
TI  - From serendipity to design: the evolution of drug development in oncology
DP  - 1997 Mar 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 155--163
VI  - 64
IP  - 3
4099  - http://www.ccjm.org/content/64/3/155.short
4100  - http://www.ccjm.org/content/64/3/155.full
SO  - Cleve Clin J Med1997 Mar 01; 64
AB  - Although screening of natural products remains the major method of discovering new anticancer drugs, newer techniques of rational drug design, computer-aided drug design, and combinatorial synthesis promise to broaden the scope of compounds available for screening. Recent changes in Food and Drug Administration rules allow for accelerated approval of drugs for treating cancer and other life-threatening illnesses, although the three-phase process of clinical trials remains largely unchanged.