RT Journal Article
SR Electronic
T1 From serendipity to design: the evolution of drug development in oncology
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 155
OP 163
VO 64
IS 3
A2 Maurie Markman
A1 David M. Peereboom
YR 1997
UL http://www.ccjm.org/content/64/3/155.abstract
AB Although screening of natural products remains the major method of discovering new anticancer drugs, newer techniques of rational drug design, computer-aided drug design, and combinatorial synthesis promise to broaden the scope of compounds available for screening. Recent changes in Food and Drug Administration rules allow for accelerated approval of drugs for treating cancer and other life-threatening illnesses, although the three-phase process of clinical trials remains largely unchanged.