TY - JOUR T1 - From serendipity to design: the evolution of drug development in oncology JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 155 LP - 163 VL - 64 IS - 3 AU - David M. Peereboom A2 - Markman, Maurie Y1 - 1997/03/01 UR - http://www.ccjm.org/content/64/3/155.abstract N2 - Although screening of natural products remains the major method of discovering new anticancer drugs, newer techniques of rational drug design, computer-aided drug design, and combinatorial synthesis promise to broaden the scope of compounds available for screening. Recent changes in Food and Drug Administration rules allow for accelerated approval of drugs for treating cancer and other life-threatening illnesses, although the three-phase process of clinical trials remains largely unchanged. ER -