RT Journal Article SR Electronic T1 Thrombolytic therapy JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 189 OP 196 VO 56 IS 2 A2 Vidt, Donald G. A2 Bakst, Alan W. A1 Stewart, James H. A1 Olin, Jeffrey W. A1 Graor, Robert A. YR 1989 UL http://www.ccjm.org/content/56/2/189.abstract AB Despite the discovery of thrombolytic agents more than 50 years ago, only recently has major interest become evident in their use to treat myocardial infarction, venous thromboembolism, and peripheral arterial disease. Use of thrombolytic drugs may result in myocardial and limb salvage as well as improved survival rates and quality of life for patients affected by potentially devastating vascular disease. W e review historical highlights, outstanding studies, and important aspects of thrombolytic therapy, emphasizing its use in peripheral vascular disease.