PT  - JOURNAL ARTICLE
AU  - Harry W. Kestler
AU  - Bimal K. Chakrabarti
TI  - A live-virus “suicide” vaccine for human immunodeficiency virus
DP  - 1997 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 269--274
VI  - 64
IP  - 5
4099  - http://www.ccjm.org/content/64/5/269.short
4100  - http://www.ccjm.org/content/64/5/269.full
SO  - Cleve Clin J Med1997 May 01; 64
AB  - A vaccine that uses a live, attenuated human immunodeficiency virus (HIV) may offer the best hope of a vaccine against acquired immunodeficiency syndrome (AIDS). A recent improvement should increase the safety of the live-virus approach: a "suicide gene" inserted into the viral RNA, which causes infected cells to die when treated with ganciclovir. We envision using this strategy not only to prevent AIDS, but also to treat it.