RT Journal Article
SR Electronic
T1 A live-virus “suicide” vaccine for human immunodeficiency virus
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 269
OP 274
VO 64
IS 5
A1 Kestler, Harry W.
A1 Chakrabarti, Bimal K.
YR 1997
UL http://www.ccjm.org/content/64/5/269.abstract
AB A vaccine that uses a live, attenuated human immunodeficiency virus (HIV) may offer the best hope of a vaccine against acquired immunodeficiency syndrome (AIDS). A recent improvement should increase the safety of the live-virus approach: a "suicide gene" inserted into the viral RNA, which causes infected cells to die when treated with ganciclovir. We envision using this strategy not only to prevent AIDS, but also to treat it.