PT  - JOURNAL ARTICLE
AU  - Korfali, E.
AU  - Knowles, W. Douglas
AU  - Uysal, Sait
AU  - Iulus, I. Hakk
AU  - Ozmen, Tulin
TI  - Fetal substantia nigra grafts
DP  - 1989 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 259--262
VI  - 56
IP  - 3
4099  - http://www.ccjm.org/content/56/3/259.short
4100  - http://www.ccjm.org/content/56/3/259.full
SO  - Cleve Clin J Med1989 May 01; 56
AB  - Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hy-droxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7 % increase of [3H] spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25 % decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A non-significant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.