RT Journal Article
SR Electronic
T1 Fetal substantia nigra grafts
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 259
OP 262
VO 56
IS 3
A1 Korfali, E.
A1 Knowles, W. Douglas
A1 Uysal, Sait
A1 Iulus, I. Hakk
A1 Ozmen, Tulin
YR 1989
UL http://www.ccjm.org/content/56/3/259.abstract
AB Effects of fetal substantia nigra grafts on the dopamine receptors in the corpus striatum in rats were investigated after the destruction of the nigrostriatal dopaminergic pathways with intraventricular 6-hy-droxydopamine injections. The expected dopamine receptor denervation supersensitivity was demonstrated by a 53.7 % increase of [3H] spiroperidol binding in rats with sham grafts compared with normal control-group rats. In contrast, rats with grafts showed a significant reduction of supersensitivity, with a 25 % decrease in binding to the graft-bearing caudate when compared with the sham-graft group. A non-significant 15% decrease in binding on the nongrafted side was also observed. The fetal substantia nigra grafts thus reduced the denervation supersensitivity toward a normal level.