PT - JOURNAL ARTICLE AU - Mazanec, Daniel J. AU - Grisanti, Joseph M. TI - Drug-induced osteoporosis DP - 1989 May 01 TA - Cleveland Clinic Journal of Medicine PG - 297--303 VI - 56 IP - 3 4099 - http://www.ccjm.org/content/56/3/297.short 4100 - http://www.ccjm.org/content/56/3/297.full SO - Cleve Clin J Med1989 May 01; 56 AB - Use of corticosteroids has been most frequently associated with bone loss, but heparin and methotrexate, when used in relatively high doses, have also been linked to the development of osteoporosis. Clinical features of bone loss associated with these agents, possible pathophysiologic mechanisms, and strategies for avoiding this complication are reviewed.