PT  - JOURNAL ARTICLE
AU  - Ferrario, Carlos M.
AU  - Schiavone, Marc T.
TI  - The renin angiotensin system: importance in physiology and pathology
DP  - 1989 Jun 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 439--446
VI  - 56
IP  - 4
4099  - http://www.ccjm.org/content/56/4/439.short
4100  - http://www.ccjm.org/content/56/4/439.full
SO  - Cleve Clin J Med1989 Jun 01; 56
AB  - Angiotensin II has long been recognized as a key factor in cardiovascular regulation. The effectiveness of angiotensin-converting enzyme (ACE) inhibitors in controlling essential hypertension suggests that angiotensin II plays a key role in its pathology. The tools of molecular biology have provided the means for a critical reassessment of the renin-antiotensin-aldosterone system in physiology and pathology. The analysis has shown that angiotensin peptides are also synthesized and processed locally in a variety of tissues, including the vascular wall, adrenal glands, heart, and brain. Since angiotensin II is a potent modulator of cardiovascular control centers in the brain, the hypothesis is now advanced that a defect in the brain renin-angiotensin-aldosterone system contributes to the development of hypertensive disease.