PT - JOURNAL ARTICLE ED - Wilke, William S. AU - Barkan, Ariel L. TI - New options for diagnosing and treating acromegaly DP - 1998 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 343--349 VI - 65 IP - 7 4099 - http://www.ccjm.org/content/65/7/343.short 4100 - http://www.ccjm.org/content/65/7/343.full SO - Cleve Clin J Med1998 Jul 01; 65 AB - Insulin-like growth factor 1 (IGF-1) is the final pathway of the growth hormone cascade, and is a better clinical measure of acromegaly than growth hormone itself. In patients with acromegaly, medical treatment w i t h a somatostatin analog normalizes growth hormone and IGF-1 levels and produces clinical improvement quickly.