RT Journal Article SR Electronic T1 Heparin-induced thrombocytopenia JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 483 OP 490 VO 56 IS 5 A2 William R. Hart A1 Michael L. Miller YR 1989 UL http://www.ccjm.org/content/56/5/483.abstract AB Thrombocytopenia is a lesser known but significant complication of heparin therapy. Heparin-dependent, antibody-mediated thrombocytopenia may be accompanied by hemorrhagic or thrombotic sequelae. Thrombosis is more frequent and is associated with significant morbidity and mortality. Diagnostic laboratory findings include a variable reduction in the platelet count during heparin administration and the presence of heparin-dependent platelet-associated antibodies that can induce in vitro platelet aggregation. Discontinuing heparin is the primary treatment, although other therapies may be used. This review discusses clinical features, pathophysiology, laboratory findings, and treatment alternatives.