PT  - JOURNAL ARTICLE
AU  - Fishleder, Andrew J.
TI  - Immunoglobulin and T-cell receptor gene rearrangement
DP  - 1989 Oct 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 716--721
VI  - 56
IP  - 7
4099  - http://www.ccjm.org/content/56/7/716.short
4100  - http://www.ccjm.org/content/56/7/716.full
SO  - Cleve Clin J Med1989 Oct 01; 56
AB  - Recent studies have significantly broadened understanding of immunoglobulin production and T-cell receptor formation at the gene level. A limited number of genes can be rearranged during the course of B-cell or T-cell development to yield unique DNA sequences that will code for specific antibodies and T-cell receptor proteins. Southern blot hybridization analysis allows sensitive examination of lymphocyte DNA for the presence or absence of gene rearrangements. General mechanisms that underlie immunoglobulin and T-cell receptor rearrangement are reviewed, along with the diagnostic applications of detection of gene rearrangement by Southern blot hybridization technique.