PT - JOURNAL ARTICLE AU - Elizabeth H. Danish AU - John W. Harris AU - Kelly Oh TI - Solidity of sickle hemoglobin gels: relevance to pathophysiology of sickling disorders DP - 1989 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 793--800 VI - 56 IP - 8 4099 - http://www.ccjm.org/content/56/8/793.short 4100 - http://www.ccjm.org/content/56/8/793.full SO - Cleve Clin J Med1989 Nov 01; 56 AB - The physical properties of hemoglobin (Hb) S gels formed under conditions relevant to in vivo conditions have been characterized using viscometry. Mixed Hb SF and Hb AS gels of hemoglobin concentrations and compositions found in patients with Hb S-HPFH (mild sickle-cell disease) and Hb AS (sickle-cell trait) have been compared to those of pure Hb S. The results may explain why red cells containing gels occlude the microcirculation and/or undergo hemolysis in patients with sickle-cell anemia, why patients with Hb S-HPFH are mildly affected with red-cell sickling, and why individuals with Hb AS have no clinical manifestations of the Hb abnormality.