PT - JOURNAL ARTICLE AU - Leslie Cho TI - A practical approach to the cholesterol guidelines and ASCVD prevention AID - 10.3949/ccjm.87.s1.02 DP - 2020 May 01 TA - Cleveland Clinic Journal of Medicine PG - 15--20 VI - 87 IP - 5 suppl 1 4099 - http://www.ccjm.org/content/87/5_suppl_1/15.short 4100 - http://www.ccjm.org/content/87/5_suppl_1/15.full SO - Cleve Clin J Med2020 May 01; 87 AB - Lifestyle factors remain the bedrock of atherosclerotic cardiovascular disease (ASCVD) prevention. Statins remain the first-line therapy for primary and secondary prevention of ASCVD. Physicians are encouraged to discuss the risks and benefits of statins with patients before beginning therapy. Nonstatins and proprotein convertase subtilisin-kexin type 9 inhibitors are recommended for secondary prevention in patients with clinical ASCVD. For patients at intermediate risk of ASCVD, new risk-enhancing factors, including chronic inflammatory conditions and ethnicity, should be considered to better risk stratify these patients.