RT Journal Article SR Electronic T1 A practical approach to the cholesterol guidelines and ASCVD prevention JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 15 OP 20 DO 10.3949/ccjm.87.s1.02 VO 87 IS 5 suppl 1 A1 Cho, Leslie YR 2020 UL http://www.ccjm.org/content/87/5_suppl_1/15.abstract AB Lifestyle factors remain the bedrock of atherosclerotic cardiovascular disease (ASCVD) prevention. Statins remain the first-line therapy for primary and secondary prevention of ASCVD. Physicians are encouraged to discuss the risks and benefits of statins with patients before beginning therapy. Nonstatins and proprotein convertase subtilisin-kexin type 9 inhibitors are recommended for secondary prevention in patients with clinical ASCVD. For patients at intermediate risk of ASCVD, new risk-enhancing factors, including chronic inflammatory conditions and ethnicity, should be considered to better risk stratify these patients.