PT  - JOURNAL ARTICLE
AU  - Charles Camisa
AU  - Thomas M. O’Dorisio
AU  - Ronald F. Maceyko
AU  - Gretchen E. Schacht
AU  - Hagop S. Mekhjian
AU  - Brent A. Howe
TI  - Treatment of psoriasis with chronic subcutaneous administration of somatostatin analog 201-995 (Sandostatin)
DP  - 1990 Jan 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 71--76
VI  - 57
IP  - 1
4099  - http://www.ccjm.org/content/57/1/71.short
4100  - http://www.ccjm.org/content/57/1/71.full
SO  - Cleve Clin J Med1990 Jan 01; 57
AB  - Increased levels of human growth hormone (HGH) may correlate with the severity of psoriasis and native somatostatin (SRIF) may improve it by inhibiting HGH release. The synthetic SRIF analog, SMS 201-995, is a potent and long-lasting HGH inhibitor. Nine patients with chronic plaque psoriasis completed 12 weeks of open treatment with SMS 201-995. Overall improvement was minimal to marked in six patients and unchanged in three; none worsened. Means of 24-hour pooled HGH (1.7 ± 0.7 μg/L) and fasting plasma somatomedin-C (SM - C) (0.45 ± 0.22 U/mL) were normal at baseline and were not significantly altered by treatment. A high frequency of gastrointestinal side effects occurred, but no patient discontinued treatment because of them. SMS 201-995 may be a useful therapy for psoriasis, but its mechanism of action is unknown. Double-blind placebo-controlled trials are currently in progress to confirm the efficacy of SMS 201-995 in psoriasis.