RT Journal Article
SR Electronic
T1 Treatment of psoriasis with chronic subcutaneous administration of somatostatin analog 201-995 (Sandostatin)
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 71
OP 76
VO 57
IS 1
A1 Charles Camisa
A1 Thomas M. O’Dorisio
A1 Ronald F. Maceyko
A1 Gretchen E. Schacht
A1 Hagop S. Mekhjian
A1 Brent A. Howe
YR 1990
UL http://www.ccjm.org/content/57/1/71.abstract
AB Increased levels of human growth hormone (HGH) may correlate with the severity of psoriasis and native somatostatin (SRIF) may improve it by inhibiting HGH release. The synthetic SRIF analog, SMS 201-995, is a potent and long-lasting HGH inhibitor. Nine patients with chronic plaque psoriasis completed 12 weeks of open treatment with SMS 201-995. Overall improvement was minimal to marked in six patients and unchanged in three; none worsened. Means of 24-hour pooled HGH (1.7 ± 0.7 μg/L) and fasting plasma somatomedin-C (SM - C) (0.45 ± 0.22 U/mL) were normal at baseline and were not significantly altered by treatment. A high frequency of gastrointestinal side effects occurred, but no patient discontinued treatment because of them. SMS 201-995 may be a useful therapy for psoriasis, but its mechanism of action is unknown. Double-blind placebo-controlled trials are currently in progress to confirm the efficacy of SMS 201-995 in psoriasis.