PT  - JOURNAL ARTICLE
AU  - Orlowski, James P.
AU  - Campbell, Peter
AU  - Goldstein, Stanley
TI  - Reye’s syndrome: a case control study of medication use and associated viruses in Australia
DP  - 1990 Jun 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 323--329
VI  - 57
IP  - 4
4099  - http://www.ccjm.org/content/57/4/323.short
4100  - http://www.ccjm.org/content/57/4/323.full
SO  - Cleve Clin J Med1990 Jun 01; 57
AB  - The records of 49 cases of Reye’s syndrome at three pediatric hospitals in Australia are compared with 94 controls. The diagnosis of Reye’s syndrome was confirmed pathologically in 42 of 49 cases (86%). Aspirin or salicylate ingestion occurred in only 4 (8%), and paracetamol (acetaminophen) ingestion in 12 (24%) (P>0.05 by chi-square analysis). Of the controls, 3 (3%) had taken aspirin and 39 (41%) had taken paracetamol. Associated viruses included paramyxoviruses, picornaviruses, reoviruses, adenoviruses, and occasional varicella-zoster (herpesvirus). No influenza A or B viruses were recovered from any patient. This case control study of Reye’s syndrome in Australia confirmed a lack of association between aspirin ingestion and the development of Reye’s syndrome.