@article {Brouhard513, author = {Samuel J. Hassenbusch and James H. Anderson and Donald M. Whiting}, editor = {Brouhard, Ben H.}, title = {Intra-arterial chemotherapy for brain tumors}, volume = {57}, number = {6}, pages = {513--520}, year = {1990}, publisher = {Cleveland Clinic Journal of Medicine}, abstract = {Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-l-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as B C N U diluent. When ethanol was used as a diluent, right (infused) hemisphere deft (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs.}, issn = {0891-1150}, URL = {https://www.ccjm.org/content/57/6/513}, eprint = {https://www.ccjm.org/content/57/6/513.full.pdf}, journal = {Cleveland Clinic Journal of Medicine} }